The alignment of editing-ON and editing-OFF scans is an issue for all J-difference-edited MRS, but especially for HERMES editing, where at least four sub-experiments (with different signal characteristics) must be aligned.

We are going to be taking a shotgun approach to improving frequency-and-phase correction for HERMES. Tomorrow, we will focus on HERMES of GABA and GSH, trialling a (hopefully large) number of methods on 4x10 subjects in vivo data (collected at three sites) and simulated data. We will implement the best method(s) in Gannet and hope to publish the results soon after.