Georg Oeltzschner, PhD

My research is dedicated to developing modern techniques to measure levels of important biochemicals in the living human brain using magnetic resonance spectroscopy. I’m particularly focused on improving the detection of neurotransmitters (GABA, glutamate, aspartate), antioxidants (glutathione, ascorbate), and potential molecular markers of brain tumor mutations (2-hydroxyglutarate, cystathionine).

The techniques I develop are used to investigate the neurochemical confounds in a wide range of neurological and psychiatric disorders. Currently, I study the levels of brain metabolites in patients with mild cognitive impairment. Further research projects I am involved in concern various neurodevelopmental disorders (autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette’s syndrome), tuberous sclerosis, hepatic encephalopathy, and glioma.

A recent major focus of my attention is the standardization of data acquisition and analysis. I believe that the magnetic resonance spectroscopy community can reap great benefit from embracing the practices of the Open Science movement: We need to adapt code sharing, standardize our acquisition, and streamline our pipelines for processing, quantifying, and interpreting spectroscopic data.

You can find my fully open-source MRS data analysis toolbox Osprey on GitHub, including a complete documentation.

• e-mail: goeltzs1 [at] jhmi [dot] edu

• Web: Specfitlab

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