A reading list on Advanced Editing

In setting up a new project, I recently wrote a reading list for someone coming new to edited MRS from outside the area. I thought it would be useful to post here for future reference and for anyone getting started.

Before you understand Advanced Editing, you need a grasp of edited MRS in general, so I’d suggest starting with a couple of reviews. There is other literature out there (including by other groups), but I reference our papers and the minimal reading.

  • Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. Neuroimage. 2014;86:43-52.  doi: 10.1016/j.neuroimage.2012.12.004. Epub 2012 Dec 13.

    This review focuses on J-difference-edited MRS of GABA, but should be a good starting point for the basic principles.

  • Edited 1 H magnetic resonance spectroscopy in vivo: Methods and metabolites.

    Harris AD, Saleh MG, Edden RA. Magn Reson Med. 2017 Apr;77(4):1377-1389. doi: 10.1002/mrm.26619.

    This review broadens out into other metabolites that can be edited and also includes a little more detail about the mechanism of J-difference editing.

Then, moving beyond editing in general, some papers that describe editing more than one metabolite, using HERMES and HERCULES

  • HERMES: Hadamard encoding and reconstruction of MEGA-edited spectroscopy.

    Chan KL, Puts NA, Schär M, Barker PB, Edden RA. Magn Reson Med. 2016 Jul;76(1):11-9. doi: 10.1002/mrm.26233.

    This paper described the idea of Hadamard encoded editing and its application to separating signals from NAA and NAAG.

  • Simultaneous edited MRS of GABA and glutathione.

    Saleh MG, Oeltzschner G, Chan KL, Puts NAJ, Mikkelsen M, Schär M, Harris AD, Edden RAE. Neuroimage. 2016 Nov 15;142:576-582. doi: 10.1016/j.neuroimage.2016.07.056.

    We then applied the same principle to editing GABA and GSH in a single experiment.

  • Advanced Hadamard-encoded editing of seven low-concentration brain metabolites: Principles of HERCULES. Oeltzschner G, Saleh MG, Rimbault D, Mikkelsen M, Chan KL, Puts NAJ, Edden RAE. Neuroimage. 2019 Jan 15;185:181-190. doi: 10.1016/j.neuroimage.2018.10.002. 

    Next, we tried to edit everything in a single experiment HERCULES, which used a more elaborate editing scheme and multi-spectrum modeling.

In addition to editing more than one metabolite, we have also developed ways of editing more than one voxel, using PRIAM.

  • Parallel reconstruction in accelerated multivoxel MR spectroscopy.

    Boer VO, Klomp DW, Laterra J, Barker PB. Magn Reson Med. 2015 Sep;74(3):599-606. doi: 10.1002/mrm.25718.

    The original PRIAM concept was developed by Vincent Boer…

  • Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy.

    Oeltzschner G, Puts NA, Chan KL, Boer VO, Barker PB, Edden RA. Magn Reson Med. 2017 Jan;77(1):16-22. doi: 10.1002/mrm.26536.

    …and it was applied to editing here. This paper includes proof-of-principle for the combination of HERMES-PRIAM for multi-voxel, multi-metabolite editing.